Alteration of Ornithine Metabolic Pathway in Colon Cancer and Multivariate Data Modelling for Cancer Diagnosis

It is noteworthy that colon cancer the fourth place in new cases and fifth mortalities according to global statistics 2018. Tumorigenesis displays specific correlation with metabolic alterations. A variety of metabolites, including ornithine (Orn), are related sources disease information retrieval human metabolome database. The regulation Orn pathway a key link survival cells. In this study, plasma levels patients healthy participants were measured by liquid chromatography tandem mass spectrometry, disturbances identified. Based on exploring structure metabolism via MetaboAnalyst Kyoto Encyclopedia Genes Genomes database, we found upstream downstream metabolites included arginine (Arg) N1, N12-diacetylspermine (DiAcSpm). We observed Arg-Orn-DiAcSpm was up-regulated through analysis. used multivariate data modelling build regression diagnosis model based three for cancer, capability analyzed receiver operating characteristic curve. This study provides theoretical basis further feature description tumor pathway, which may lead discover therapeutic targets drugs against cancer. Multivariate expected be novel technology developing noninvasive screening tool